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Bioactive Inorganic Scaffolds

Inorganic ScaffoldThe development of inorganic scaffold materials for bone regeneration at FMZ is based on reactive calcium- and magnesium phosphates (CaP and MgP) that set after addition of water under ambient conditions, without the need for sintering.

Primary aims are focused on the reactivity of the powders, their rheological optimization for injectability, and the mechanical strength of the resulting ceramics.

Our cement powders are also used for rapid-prototyping by 3D printing techniques for the construction of individualized geometries with aInorganic Scaffold high lateral resolution (Figure right top) and precisely defined macropores for blood vessel ingrowth (Figure left).

Recent developments concern the use of microporous CaP-scaffolds as drug carriers. Through the use of multicolour-printers, bioactive compounds can be added at desired locations in the 3D scaffolds for a spatial control of tissue response and drug release kinetics.

One main strategy followed at FMZ to improve the typical brittle fracture behaviour of phospohate cements is integration of reinforcing fibers (Figure right bottom). To obtain strong and tough composites, interaction of fibers and matrix as well as the degradation behavior of fibers and matrix are optimized and synchronized.

Inorganic ScaffoldHigh and open porosity is a crucial property to allow vascularization and cell infiltration. One approach followed at FMZ is replication of polymeric foams with a suitable post-treatment to gain highly porous scaffolds with the strongest possible mechanical strenght.

Prof. Dr. rer. nat. Uwe Gbureck
Telephone +49(0)931 20173550

Electrochemically assisted deposition of ceramic coatings

The biocompatibility especially of non-degradable implant materials arises from its surface.
Biointerface EngineeringElectrochemically assisted deposition is used to equip metallic surfaces with low-crystalline calcium and magnesium phosphate coatings. One aim of these studies is the development of novel multi-phase coatings with incorporated ions, which combine bactericidal and bioactive properties and hence can decrease the risk of inflammation after surgery and support the subsequent in-growth of the medical implant.

Dr. rer. nat. Claus Moseke

Telephone +49(0)931 3189092

Ph.D. students and scientific co-workers:

M. Sc. Theresa Brückner
Novel application forms of mineral bone cements
09 31 - 201 73530

M. Sc. Markus Meininger
Elektrochemically assisted and elektrophoretic deposition of bioceramics
09 31 - 201 73530

M. Sc. Susanne Meininger
Fiber reinforcement and 3D powder printing of calcium and magnesium phosphate cements
09 31 - 201 73530

Pharmacist Michaela Rödel
Dual setting mineral cements with polymerizable matrix of biodegradable polymers
09 31 - 201 73554

Dipl.-Ing. Martha Schamel
Dual setting calcium/magnesium phosphate cement systems
09 31 - 201 73591

Dr. rer. nat. Elke Vorndran
3D powder printing of calcium and magnesium phosphate cement systems and drug delivery systems
09 31 - 3189083

Photo | Research | CV

M. Meininger, C. Wolf-Brandstetter, J. Zerweck, F. Wenninger, U. Gbureck, J. Groll, C. Moseke. Electrochemically assisted deposition of strontium modified magnesium phosphate on titanium surfaces. Materials Science and Engineering C 2016; 67: 65-71

A. Kumar, S. Mandala, S. Baruia, R. Vasireddia, U. Gbureck, M. Gelinsky, B. Basu. Low temperature additive manufacturing of three dimensional scaffolds for bone-tissue engineering applications: Processing related challenges and property assessment. Materials Science and Engineering R: Reports 2016; 103: 1-39

T. Brückner, M. Schamel, A.C. Kübler, J. Groll, U. Gbureck. Novel bone wax based on poly(ethylene glycol)–calcium phosphate cement mixtures Acta Biomaterialia 2016; published online

M. Meininger, T. Schmitz, T. Wagner, A. Ewald, U. Gbureck, J. Groll, C. Moseke. Real-time measurement of protein adsorption on electrophoretically deposited hydroxyapatite coatings and magnetron sputtered metallic films using the surface acoustic wave technique. Materials Science and Engineering C 2016; 61: 351-354

S. Meininger, S. Mandal, A. Kumar, J. Groll, B. Basub, U. Gbureck. Strength reliability and in vitro degradation of three-dimensional powder printed strontium-substituted magnesium phosphate scaffolds. Acta Biomaterialia 2016, published online

A. Manchón, M.H. Alkhraisat, C. Rueda-Rodriguez, J.C. Prados-Frutos, J. Torres, J. Lucas-Aparicio, A. Ewald, U. Gbureck, E. López-Cabarcos. A new iron calcium phosphate material to improve the osteoconductive properties of a biodegradable ceramic: a study in rabbit calvaria. Biomedical Materials 2015, 10(5), published online

K. Zorn, E. Vorndran, U. Gbureck, F.A. Müller. Reinforcement of a magnesium-ammonium-phosphate cement with calcium phosphate whiskers. Journal of the American Ceramic Society 2015, published online

M. Geffers, J. Groll, U. Gbureck. Reinforcement Strategies for Load-Bearing Calcium Phosphate Biocements. Materials 2015; published online

Z. Sheikh, M. Geffers, T. Christel, J. Barralet, U. Gbureck. Chelate setting of alkali ion substituted calcium phosphates. Ceramics International 2015; published online

E. Vorndran, C. Moseke, U. Gbureck. 3D printing of ceramic implants. MRS Bulletin 2015; 40(2): 127-136

T. Christel, S. Christ, J.E. Barralet, J. Groll, U. Gbureck. Chelate Bonding Mechanism in a Novel Magnesium Phosphate Bone Cement. Journal of the American Ceramic Society 2015; 98(3): 694-697

M. Castilho, J. Rodrigues, I. Pires, B. Gouveia, M. Pereira, C. Moseke, J. Groll, A. Ewald, E. Vorndran. Fabrication of individual alginate-TCP scaffolds for bone tissue engineering by means of powder printing. Biofabrication 2015; 7, published online

M. Geffers, J.E. Barralet, J. Groll, U. Gbureck. Dual-setting brushite-silica gel cements. Acta Biomaterialia 2015; 11: 467-476

S. Christ, M. Schnabel, E. Vorndran, J. Groll, U. Gbureck. Fiber reinforcement during 3D printing. Materials Letters 2015; 139: 165-168

S.N. Rath, A. Brandl, D. Hiller, A. Hoppe, U. Gbureck, R.E. Horch, A.R. Boccaccini, U. Kneser. Bioactive Copper-Doped Glass Scaffolds Can Stimulate Endothelial Cells in Co-Culture in Combination with Mesenchymal Stem Cells. Plos One 2014; published online

P. Schendzielorz, T. Schmitz, C. Moseke, U. Gbureck, K. Frölich, K. Rak, J. Groll, R. Hagen, A. Radeloff. Plasma-Assisted Hydrophilization of Cochlear Implant Electrode Array Surfaces Enables Adhesion of Neurotrophin-Secreting Cells. ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery 2014; 76: 257-265

S. Flauder, U. Gbureck, F.A. Müller. Structure and mechanical properties of β-TCP scaffolds prepared by ice-templating with preset ice front velocities. Acta Biomaterialia 2014; 10(12): 5148-5155

T. Schmitz, F. Warmuth, E. Werner, C. Hertl, J. Groll, U. Gbureck, C. Moseke. Physical and chemical characterization of Ag-doped Ti coatings produced by magnetron sputtering of modular targets. Materials Science and Engineering C 2014; 44: 126-131

T. Christel, M. Geffers, U. Klammert, B. Nies, A. Höß, J. Groll, A.C. Kübler, U. Gbureck. Fabrication and cytocompatibility of spherical magnesium ammonium phosphate granules. Materials Science & Engineering C 2014; 42: 130-136

B. Kanter, M. Geffers, A. Ignatius, Uwe Gbureck. Control of in vivo mineral bone cement degradation. Acta Biomaterialia 2014; 10(7): 3279-3287

A. Manchón, M. Alkhraisat, C. Rueda-Rodriguez, J. Torres, J.C. Prados-Frutos, A. Ewald, U. Gbureck, J. Cabrejos-Azama, A. Rodriguez-González, E. López-Cabarcos. Silicon calcium phosphate ceramic as novel biomaterial to simulate the bone regenerative properties of autologous bone. Journal of Biomedical Materials Research Part A 2014; published online

F. Tamimi, J. Torres, K. Al-Abedalla, E. Lopez-Cabarcos, M.H. Alkhraisat, D.C. Bassett, U. Gbureck, J.E. Barralet. Osseointegration of dental implants in 3D-printed synthetic onlay grafts customized according to bone metabolic activity in recipient site. Biomaterials 2014; 35(21): 5436-5445

C. Hertl, L. Koll, T. Schmitz, E. Werner, U. Gbureck. Structural characterisation of oxygen diffusion hardened alpha-tantalum PVD-coatings on titanium. Materials Science & Engineering C 2014; 41: 28-35

M. Castilho, M. Dias, E. Vorndran, U. Gbureck, P. Fernandes, I. Pires, B. Gouveia, H. Armés, E. Pires, J. Rodrigues. Application of a 3D printed customized implant for canine cruciate ligament treatment by tibial tuberosity advancement Biofabrication 2014; published online.

K. Stuckensen, A. Ewald, J. Groll, U. Gbureck. In situ formation of multilayer biocomposite with anisotropic crystal orientation. Materials Letters 2014; 120(1): 111-114.

M. Castilho, C. Moseke, A. Ewald, U. Gbureck, J. Groll, I. Pires, J. Tessmar, E. Vorndran. Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects. Biofabrication 2014; 6(1), published online

E. Vorndran, M. Geffers, A. Ewald, M. Lemm, B. Nies, U. Gbureck. Ready-to-use injectable calcium phosphate bone cement paste as drug carrier. Acta Biomaterialia 2013; 9(12):9558–9567.

M. Castilho, M. Dias, U. Gbureck, J. Groll, P. Fernandes, I. Pires, B. Gouveia, J. Rodrigues, E. Vorndran. Fabrication of computationally designed scaffolds by low temperature 3D printing. Biofabrication 2013; 5, published online.

N. Mehrban, J. Bowen, E. Vorndran, U. Gbureck, L.M. Grover. Structural changes to resorbable calcium phosphate bioceramic aged in vitro. Colloids and Surfaces B: Biointerfaces 2013; 111: 469-478.

L.M. Grover, A.J. Wright, U. Gbureck, A. Bolarinwa, J. Song, Y. Liu, D.F. Farrar, G. Howling, J. Rose, J.E. Barralet. The effect of amorphous pyrophosphate on calcium phosphate cement resorption and bone generation. Biomaterials 2013; 34 : 6631-6637.

L.A. Strobel, N. Hild, D. Mohn, W. J. Stark, A. Hoppe, U. Gbureck, R. E. Horch, U. Kneser, A.R. Boccaccini. Novel strontium-doped bioactive glass nanoparticles enhance proliferation and osteogenic differentiation of human bone marrow stromal cells. J Nanoparticle Res 2013; 15:1780.

S. Wächter, C. Moseke, J. Groll, U. Gbureck. Emulsion synthesis of dicalcium phosphate particles for the preparation of calcium phosphate cements with improved compressive strengths and reduced setting times. Bionanomaterials 2013; 14(1-2): 81-87

J. Schnieders, U. Gbureck, M. Kratz, D.B. Jones, T. Kissel, O. Germershaus. Ex vivo human trabecular bone model for biocompatibility evaluation of calcium phosphate composites modified with spray dried biodegradable microspheres. Advanced Healthcare Materials 2013, 2(10): 1361-1369

C. Wolf-Brandstetter, S. Roessler, S. Storch, U. Hempel, U. Gbureck, B. Nies, S. Bierbaum, D. Scharnweber. Physicochemical and cell biological characterization of PMMA bone cements modified with additives to increase bioactivity. J Biomed Mater Res B 2013; 101B: 599–609.

K. Zorn, D. Mitró, E. Vorndran, U. Gbureck, F.A. Müller. Hydrothermal synthesis of calcium-deficient hydroxyapatite whiskers and their thermal transformation to polycrystalline ß-tricalcium phosphate short fibers. Bioinspired, Biomimetic and Nanobiomaterials 2013; 2(1): 11-19

C. Moseke, M. Gelinsky, J. Groll, U. Gbureck. Chemical Characterization of hydroxyapatite obtained by wet chemistry in the presence of V, Co, and Cu ions. Materials Science and Engineering C 2013; 33(3): 1654-1661

S. Flauder, U. Gbureck, F.A. Müller. ß-TCP Scaffolds with an Interconnected and Aligned Porosity Fabricated via Ice-Templating. Key Engineering Materials 2013; 529-530: 129-132

C. Moseke, C. Lehmann, T. Schmitz, F. Reinert, J. Groll, U. Gbureck. Nanostructuring of Refractory Metal Surfaces by Electrochemical Oxidation: Nb and the Binary Systems Ti-Ta and Nb-Ta. Current Nanoscience 2013; 9(1): 132-138

T. Schmitz, C. Hertl, E. Werner, U. Gbureck, J. Groll, C. Moseke. Oxygen diffusion hardening of tantalum coatings on cp-titanium for biomedical applications. Surface & Coatings Technology 2013; 216: 46–51

T. Christel, M. Kuhlmann, E. Vorndran, J. Groll, U. Gbureck. Dual setting α-tricalcium phosphate cements. Journal of Materials Science: Materials in Medicine 2013; 24(3): 573-581

C. Moseke, C. Bayer, E. Vorndran, J.E. Barralet, J. Groll, U. Gbureck. Low temperature fabrication of spherical brushite granules by cement paste emulsion. Journal of Materials Science: Materials in Medicine 2012; 23(11): 2631-2637

A. Ewald, C. Kaeppel, E. Vorndran, C. Moseke, M. Gelinsky, U. Gbureck. The effect of Cu(II)-loaded brushite scaffolds on growth and activity of osteoblastic cells. Journal of Biomedical Materials Research Part A 2012; 100: 2392–2400

W. Herzlieb, K.M. Koehler, A. Ewald, N. Hofmann, U. Gbureck. Antimicrobial and physicochemical properties of experimental light curing composites with alkali-substituted calcium phosphate fillers, Dental Materials 2012; 28(6):597-603.

J.Y.S. Yoon, H. Deyhle, U. Gbureck, E. Vorndran, F. Beckmann, B. Mueller. Three-dimensional morphology and mechanics of bone scaffolds fabricated by rapid prototyping, International Journal of Materials Research 2012; 103(2): 200-206.

A. Ewald, B. Lochner, U. Gbureck, J. Groll, R. Krüger. Structural optimization of macroporous magnesium phosphate scaffolds and their cytocompatibility, Key Engineering Materials 2012; 493-494: 813-819.

C. Moseke, F. Hage, E. Vorndran, U. Gbureck. TiO2 nanotube arrays deposited on Ti substrate by anodic oxidation and their potential as a long-term drug delivery system for antimicrobial agents, Applied Surface Science 2012; 258(14): 5399-5404.

E. Vorndran, N. Spohn, B. Nies, S. Rössler, S. Storch, U. Gbureck: Mechanical properties and drug release behaviour of bioactivated PMMA-cements, Journal of Biomaterials Applications 2012; 26(5): 581-594.

J. Schnieders, U. Gbureck, E. Vorndran, M. Schossig, T. Kissel. The effect of porosity on drug release kinetics from vancomycin microsphere/calcium phosphate cement composites, JBMR B 2011; 99B(2): 391-398.

N. Mehrban, J. Z. Paxton, J. Bowen, A. Bolarinwa, E. Vorndran, U. Gbureck, L. M. Grover. Comparing physicochemical properties of printed and hand cast biocements designed for ligament replacement, Advances in Applied Ceramics 2011, 110: 162-167.

F. Tamini, D. Le Nihouannen, D.C. Bassett, S. Ibasco, U. Gbureck, J.C. Knowles, A.J. Wright, S. Komarova, J.E. Barralet: Biocompatibility of magnesium phosphate minerals and their stability under physiological conditions, Acta Biomaterialia 2011; 7: 2678-2685.

U. Klammert, A. Ignatius, U. Wolfram, T. Reuther, U. Gbureck: In vivo degradation of low temperature calcium and magnesium phosphate ceramics in a heterotopic model, Acta Biomaterialia, 2011; 7: 3469-3475.

Torres J, Tamimi F, Alkhraisat M, Prados-Frutos JC, Rastikerdar E, Gbureck U, Barralet JE, López-Cabarcos E. Vertical bone augmentation with 3D-synthetic monetite blocks in the rabbit calvaria, J Clin Periodont 2011; 38:1147-53.

Tan YN, Patel S, Gbureck U, Grover LM. Controlling degradation in calcium phosphate cements. Adv Appl Ceram 2011; 110: 457-463.

C. Moseke, U. Gbureck, P. Elter, P. Drechsler, A. Zoll, R. Thull, A. Ewald. Hard implant coatings with antimicrobial properties. Journal of Materials Science: Materials in Medicine, 22(12), 2711-2720 (2011)

E. Vorndran, K. Wunder, C. Moseke, I. Biermann, F. A. Müller, K. Zorn, U. Gbureck: Hydraulic setting Mg3(PO4)2 powders for 3D printing technology, Adv Appl Ceram 2011; 110: 476-481.

A. Ewald, D. Hösel, S. Patel, L.M. Grover, J.E. Barralet, U. Gbureck. Silver-doped calcium phosphate cements with antimicrobial activity. Acta biomaterialia, 7(11), 4064-4070 (2011)

R. Krüger, D. Joklitschke; U. Gbureck; A. Ewald. Development and Cytocompatibility Testing of Trimagnesium Phosphate and Struvite Foams. Tissue Eng A, 17(3-4), 562 (2011)

E. Vorndran, A. Ewald, F.A. Müller, K. Zorn, A. Kufner, U. Gbureck. Formation and properties of magnesium-ammonium-phosphate hexahydrate biocements in the Ca-Mg-PO(4) system. J Mater Sci Mater Med. 22(3), 429-436 (2011)

C. Moseke, V. Saratsis, U. Gbureck, Injectability and mechanical properties of magnesium phosphate cements. Journal of Materials Science: Materials in Medicine, Vol. 22, No. 12, 2011, 2591-2598

Ewald A, Helmschrott K, Knebl G, Mehrban N, Grover LM, Gbureck U. Effect of cold-setting calcium- and magnesium phosphate matrices on protein expression in osteoblastic cells. J Biomed Mater Res B Appl Biomater 2011; 96B(2): 326-332.

M. Hamdan Alkhraisat, C. Rueda, F.T. Marino, J. Torres, L. Blanco Jerez, U. Gbureck, E. Lopez Cabarcos: Effect of silica gel on the cohesion, properties and biological performance of brushite cement, Acta Biomaterialia 2010; 6: 257-265.

M. Hamdan Alkhraisat, C. Rueda, J. Cabrejos-Azama, J. Lucas-Aparicio, F. Tamimi Mariño, J. Torres García-Denche, L. Blanco Jerez, U. Gbureck, E. Lopez Cabarcos. Loading and release of doxycycline hyclate from strontium-substituted calcium phosphate cement. Acta Biomaterialia 2010; 6: 1522-1528.

A. Bolarinwa, U. Gbureck, P. Purnell, M. Bold, L. M. Grover: Cement casting of calcium pyrophosphate based bioceramics, Advances in Applied Ceramics 2010.

S. Patel, P.-J. Jiang, U. Gbureck, R. Caley, L. M. Grover: Comparing the efficacy of three bioceramic matrices for the release of vancomycin hydrochloride, J Biomed Mater Res B 2010; 93: 51-58.

U. Klammert, T. Reuther, M. Blank, I. Reske, J.E. Barralet, L.M. Grover, A.C. Kübler, U. Gbureck: Phase composition, mechanical performance and in vitro biocompatibility of hydraulic setting calcium magnesium phosphate cements, Acta Biomaterialia 2010; 6: 1529-1535.

U. Klammert, U. Gbureck, E. Vorndran, J. Rödiger, P. Meyer-Marcotty, A.C. Kübler: 3D powder printed calcium phosphate implants for reconstruction of cranial and maxillofacial defects, J Craniomaxillofac Surg 2010, 38: 565-570.

U. Klammert, E. Vorndran, T. Reuther, F.A. Müller, K. Zorn, U. Gbureck: Low temperature fabrication of magnesium phosphate cement scaffolds by 3D powder printing, J Mater Sci: Mater Med 2010, 21: 2947-2953.

Grossardt C, Ewald A, Grover LM, Barralet JE, Gbureck U. Passive and active in vitro resorption of calcium and magnesium phosphate cements by osteoclastic cells. Tissue Eng Part A. 16(12):3687-95 (2010)

Vorndran E; Klammert, U; Ewald A, Barralet JE, Gbureck U. Simultaneous Immobilization of Bioactives During 3D Powder Printing of Bioceramic Drug-Release Matrices. Adv. Funct. Mat. 20(10):1585-1591 (2010).

C. Moseke, U. Gbureck, Tetracalcium phosphate: Synthesis, properties and biomedical applications, Acta Biomaterialia 2010; 6(10): 3815

U. Klammert, T. Reuther, C. Jahn, A.C. Kübler, U. Gbureck: Biocompatibility of brushite and monetite cell culture scaffolds made by 3D powder printing, Acta Biomaterialia 2009; 5: 727-734.

Moseke C; Braun W; Ewald A. Electrochemically Deposited Ca(OH)2 Coatings as a Bactericidal and Osteointegrative Modification of Ti Implants. Adv. Eng. Mat. 11(3): B1-B6 (2009)

Moseke C; Ewald A.: Cell and protein adsorption studies using quartz crystal microgravimetry with dissipation monitoring. Materialwissenschaft und Werkstofftechnik, , 40 (1-2): 36-42 (2009)

M. Hofmann, A.R. Mohammed, Y. Perrie, U. Gbureck, J.E. Barralet. High strength resorbable brushite bone cement with controlled drug releasing capabilities, Acta Biomaterialia 2009; 5: 43-49.

Y. Liu, J. E. Barralet, U. Gbureck, R. Shelton: Influence of Calcium Phosphate Crystal Morphology on the Adhesion, Spreading and Growth of Bone Derived Cells, JBMR Part A 2009, 90A: 972-980.

J.E. Barralet, U. Gbureck, P. Habibovic, E. Vorndran, C. Gerard, C.J Doillon: Angiogenesis in calcium phosphate scaffolds by inorganic copper release, Tissue Engineering 2009; 15: 1601-1609.

M. Hamdan Alkhraisat, C. Rueda, F.T. Marino, J. Torres, L. Blanco Jerez, U. Gbureck, E. Lopez Cabarcos: The effect of hyaluronic acid on brushite cement cohesion, Acta Biomaterialia 2009, 5:3150-3156.

C. Stötzel, F.A. Müller, J.E. Barralet, F. Reinert, F. Niederdraenk, U. Gbureck: Ion adsorption behaviour of hydroxyapatite powders with different crystallinities, Colloids and Surfaces B: Biointerfaces 2009, 74: 91-95.

F. Tamimi, J. Torres, U. Gbureck, E. Lopez- Cabarcos, D.C. Basset, M. Hamdan Alkhreisat, J.E. Barralet: Craniofacial vertical bone augmentation capacity of 3D printed monolithic CaHPO4 blocks compared to autologous onlay grafts, Biomaterials 2009; 30: 6318-6326.

M. Bohner, U. Gbureck: Thermal reactions of brushite cements, J Biomed Mater Res Part B 2008, 84B: 375-385.

P. Habibovic, U. Gbureck, C.J. Doillon, D.C. Bassett, C.A. van Blitterswijk, J.E. Barralet: Osteoconduction and osteoinduction of low temperature 3D printed ceramic implants, Biomaterials, 2008; 29: 944-953.

S. Mahmood, W.M. Palin, U. Gbureck, O. Addison, M.P. Hofmann: Effect of mechanical mixing and powder to liquid ratio on the strength and reliability of a brushite bone cement, Key Engin. Mater. 2008; 361-363: 307-310.

L.M. Grover, S. Patel, Y. Hu, U. Gbureck, J.E. Barralet: Modifying brushite cement degradation using calcium alginate beads, Key. Engin. Mater. 2008; 361-363: 311-314.

P.J. Jiang, S. Patel, U. Gbureck, L.M. Grover: A comparison of the efficacy of hydroxyapatite based cements and gels as drug delivery matrices, Key. Engin. Mater. 2008; 361-363: 327-330.

U. Gbureck, T. Hölzel, I. Biermann, J.E. Barralet, L.M. Grover: Preparation of TCP / calcium pyrophosphate structures via rapid prototyping, J. Mater. Sci.: Mater. Med. 2008; 19. 1559-1563.

U. Gbureck, E. Vorndran, J.E. Barralet: Modeling vancomycin release kinetics from porous calcium phosphate ceramics comparing static and dynamic immersion conditions, Acta Biomaterialia 2008; 4: 1480-1486.

F. Tamimi, B. Kumarasami, C. Doillon, U. Gbureck, D. Le Nihouannen, E. Lopez Cabarcos, J. E. Barralet: Brushite-collagen composites for bone regeneration, Acta Biomaterialia 2008; 4: 1315-1321.

D. Le Nihouannen, S. A. Hacking, U. Gbureck, S. V. Komarova, J. E. Barralet: The use of RANKL-coated brushite cement to stimulate bone remodelling, Biomaterials, 2008; 29: 3253-3259

L.M. Grover, M.P. Hofmann, U. Gbureck, B. Kumarasami, J.E. Barralet: Frozen delivery of brushite calcium phosphate cement, Acta Biomaterialia 2008, 4: 1916-1923.

M. Hamdan Alkhraisat, C. Moseke, L. Blanco, E. Lopez-Carbacos, J. E. Barralet, U. Gbureck: Strontium modified biocements with zero order release kinetics, Biomaterials 2008; 29: 4691-4697.

D. Le Nihouannen, S. V. Komarova, U Gbureck, J E Barralet, Bioactivity of bone resorptive factor loaded on osteoconductive matrices: stability post-dehydration. European Journal of Pharmaceutics and Biopharmaceutics 2008 70: 813-818.

E. Vorndran, M. Klarner, U. Klammert, L.M. Grover, S. Patel, J.E. Barralet, U. Gbureck: 3D Powder Printing of β-Tricalcium Phosphate Ceramics using different Strategies, Advanced Biomaterials 2008; 10: B67-B71.

U. Gbureck, T. Hölzel, C. Doillon, F. A. Müller, J.E. Barralet: Direct printing of bioceramic implants with spatially localised angiogenic factors. Adv. Mater. 2007, 19: 795-800.

M.P. Hofmann, U. Gbureck, C.O. Duncan, M.S. Dover, J.E. Barralet: Carvable calcium phosphate bone substitute material, J Biomed Mater Res Part B, 2007; 83B: 1-8.

U. Gbureck, O. Knappe, N. Hoffmann, J. E. Barralet: Antimicrobial Properties of Nanocrystalline Tetracalcium Phosphate Cements, J Biomed Mater Res Part B, 2007; 83B: 132-137.

K.J. Lilley, U. Gbureck, A.J. Wright, J.C. Knowles, D.F. Farrar, J.E. Barralet: Brushite cements from polyphosphoric acid, calcium phosphate systems, J Am Ceram Soc 2007, 90(6): 1892-1898.

D. Tebbe, R. Thull, U. Gbureck: Correlation between heparin release and polymerization degree of organically modified silica ceramics from 3-methacryloxypropylpolysilsesquioxane, Acta Biomaterialia 2007; 3: 829-837.

U. Gbureck, E. Vorndran, F.A. Müller, J.E. Barralet: Low temperature direct 3D printed bioceramics and biocomposites as drug release matrices, J Controlled Release 2007; 122: 173-180.

U. Gbureck, T. Hölzel, U. Klammert, K. Würzeler, F.A. Müller, J.E. Barralet: Resorbable dicalcium phosphate bone substitutes made by 3D powder printing, Advanced Functional Materials 2007, 17: 3940-3945.

F.A. Müller, U. Gbureck, T. Kasuga, Y. Mizutani, J.E. Barralet, U. Lohbauer. Whisker reinforced calcium phosphate cements, J Am Ceram Soc 2007; 90(11): 3694-3697.

L.M. Grover, U. Gbureck, M.J. Tremayne, J.E. Barralet: Biologically mediated resorption of brushite cement in vitro, Biomaterials 2006, 27: 2178-2185.

M.P. Hofmann, A.M. Young, S.N. Nazhat, U. Gbureck, J.E. Barralet: Setting Kinetics Observation of a Brushite Cement by FTIR and DSC, Key Engineering Materials 2006; 309-311: 837-830.

N.J.S. Gorst, U. Gbureck, Y. Perrie, A.L. Hutton, M.P. Hofmann, L.M. Grover, J.E., Barralet: Effect of fiber reinforcement on the mechanical properties of brushite cement, Acta Biomaterialia 2006; 2: 95-102.

R. M. Shelton, Y. Liu, P.R. Cooper, U. Gbureck, M. J. German, J. E. Barralet: Bone marrow cell gene expression and tissue construct assembly using octacalcium phosphate microscaffolds, Biomaterials 2006; 17: 2874-2881.

U. Gbureck, J. Probst, A. Masten, R. Thull: Tribochemical Structuring and Coating of Implant Metal Surfaces with Titaniumoxide- and Hydroxyapatite-Layers, Materials Science & Engineering C 23; 2003: 461-465.

J. Probst, U. Gbureck, R. Thull: Binary nitride and oxynitride PVD coatings on Titanium for Biomedical applications, Surface and Coatings Technology 2001; 148: 226-33.

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