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NanoBio-Technology


nanobio Nanotechnology is a key technology for medicine. Nanoparticles are big enough to take up and transport drugs but also small enough to be taken up by cells and to use active biological transport mechanisms. This opens a wide potential for targeted transport especially of sensitive drugs over barriers in the body to the area and tissue of interest.

Research in FMZ focuses on nanoparticles for different purposes. Systematic studies regarding the influence of nanoparticle shape, size and surface chemistry on the interaction with cells are one area of interest. Inorganic and organic nanoparticles are used for the identification of suited ligands for the specific uptake of the particles exclusively into defined cellular populations.
nanobio
A special research area are colloidal hydrogels, so called nanogels. Their high water content predetermines them for the transport of biological macromolecules. We use inverse emulsion techniques as well as cascade reactions of self-assembly and chemical cross-linking in homogenous phase for the preparation of nanogels. Oxidative cross-linking of thiofunctional polymers for example yields nanogels that are stable in extracellular spaces in the body and in the blood, while the reductive cytosolic conditions after cellular uptake lead to rapid degradation of the particles and release of the payload.

Contact:
Dr. rer. nat. Krystyna Albrecht
Telephone +49(0)931 201 73581


Ph.D. students:
Dipl.-Chem. Susanne Feineis
Polymer- and biofunctionalized gold nanoparticles for laser-induced cell manipulation
09 31 - 31 80587

Photo | Research

M. Sc. Sonja Horvat
Functionalization of nanogels for targeted drug delivery
09 31 - 31 80587


M. Sc. Ilona Zilkowski
Biofunctionalized nanogels as cell-specific drug and gene transfer systems
09 31 - 31 80587


Publications:
S. Singh, I. Zilkowski, A. Ewald, T. Maurell-Lopez, K. Albrecht, M. Moeller, J. Groll. Mild Oxidation of Thiofunctional Polymers to Cytocompatible and Stimuli-Sensitive Hydrogels and Nanogels. Macromolecular Bioscience 2013; 13(4): 470-482.

S. Singh, F. Topuz, K. Hahn, K. Albrecht, J. Groll. Einbau aktiver Proteine und lebender Zellen in redoxsensitive Hydrogele und Nanogele durch enzymatische Vernetzung. Angewandte Chemie 2013, 52(10): 3000–3003.

K. Harrass , R. Krüger, M. Möller, K. Albrecht, J. Groll. Mechanically strong hydrogels with reversible behaviour under cyclic compression with MPa loading. Soft Matter 2013; 9(10): 2869-2877

M. Bartneck, T. Ritz, H.A. Keul, M. Wambach, J. Bornemann, U. Gbureck, J. Ehling, T. Lammers, F. Heymann, N. Gassler, T. Lüdde, C. Trautwein, J. Groll, F. Tacke. Peptide-Functionalized Gold Nanorods Increase Liver Injury in Hepatitis. ACS Nano 2012; 6(10): 8767-8777

M. Bartneck, H.A. Keul, M. Wambach, J. Bornemann, U. Gbureck, N. Chatain, S. Neuss, F. Tacke, J. Groll, G. Zwadlo-Klarwasser. Effects of nanoparticle surface-coupled peptides, functional endgroups, and charge on intracellular distribution and functionality of human primary reticuloendothelial cells. Nanomedicine: Nanotechnology, Biology and Medicine 2012; 8(8): 1282–1292

M.J. Kettel, H. Hildebrandt, K. Schaefer, M. Moeller, J. Groll. Tenside-free preparation of nanogels with high functional β‑cyclodextrin content. ACS Nano 2012; 6(9): 8087–8093

Y. Hijikata, S. Horike, D. Tanaka, J. Groll, M. Mizuno, J. Kim, M. Takatade, S. Kitagawa: Differences of crystal structure and dynamics between a soft porous nanocrystal and a bulk crystal. Chem Commun 2011, 47, 7632-7634.

K. Albrecht, M. Moeller, J. Groll: Nano- and microgels through addition reactions of functional oligomers and polymers. Advances in Polymer Science 2011, 234, 65-93.

M. Bartneck, H. A. Keul, S. Singh, K. Czaja, J. Bornemann, M. Bockstaller, M. Möller, G. Zwadlo-Klarwasser and J. Groll: Rapid uptake of gold nanorods by primary human blood phagocytes and immunomodulatory effects of surface chemistry. ACS Nano 2010, 4 (6), 3073-3086.

D. Tanaka, A. Henke, K. Albrecht, M. Moeller, K. Nakagawa, S. Kitagawa, J. Groll: Rapid Preparation of Flexible Porous Coordination Polymer Nanocrystals with Accelerated Guest Adsorption Kinetics. Nature Chemistry 2010, 2, 410-416.

M. Bartneck, H. A. Keul, G. Zwadlo-Klarwasser, J. Groll: Phagocytosis Independent Extracellular Nanoparticle Clearance by Human Immune Cells. NanoLetters 2010, 10, 59-63.

J. Groll, S. Singh, K. Albrecht, M. Moeller: Biocompatible and Degradable Nanogels via Oxidation Reactions of Synthetic Thiomers in Inverse Miniemulsion. Journal of Polymer Science Part A: Polymer Chemistry 2009; 47(20): 5543-5549.




Updated: May 30, 2017  © FMZ Uni Würzburg     Impressum